منابع مشابه
CXC chemokines in angiogenesis.
CXC chemokines display pleiotropic effects in immunity, regulating angiogenesis, and mediating organ-specific metastases of cancer. In the context of angiogenesis, CXC chemokines are a unique family of cytokines, known for their ability to behave in a disparate manner in the regulation of angiogenesis. Members that contain the 'ELR' motif are potent promoters of angiogenesis, and mediate their ...
متن کاملCXC chemokines: angiogenesis, immunoangiostasis, and metastases in lung cancer.
CXC chemokines have been found to be important in the regulation of angiogenesis and tumor-related immunity, and in promoting organ-specific metastases. This review highlights the importance of CXC chemokine ligands and receptors in mediating non-small cell lung cancer tumor-associated angiogenesis, "immunoangiostasis," and organ-specific metastases. These findings may ultimately lead to clinic...
متن کاملCXC chemokines in angiogenesis relevant to chronic fibroproliferation.
The CXC chemokines are an unique family of cytokines known for their ability to behave in a disparate manner in the regulation of angiogenesis. The mechanisms for the different activity in regulating angiogenesis by members of this chemokine family is related to the following: 1) the presence or absence of the structural/functional motif (Glutamic acid-Leucine-Arginine; 'ELR' motif) that immedi...
متن کاملMicroparticles stimulate angiogenesis by inducing ELR+ CXC-chemokines in synovial fibroblasts
Microparticles (MPs) are small membrane-vesicles that accumulate in the synovial fluids of patients with rheumatoid arthritis (RA). In the arthritic joints, MPs induce a pro-inflammatory and invasive phenotype in synovial fibroblasts (SFs). The present study investigated whether activation of SFs by MPs stimulates angiogenesis in the inflamed joints of patients with RA. MPs were isolated from J...
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Angiogenesis is a pervasive, normal biological event related to critical new blood vessel growth under both physiologic and pathologic conditions. The absolute dependence of tumorigenesis on angiogenesis has taught us several important things about aberrant angiogenesis involving neoplasia, including premalignant lesions. First, the tumor vascular system must rapidly respond to increased tissue...
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ژورنال
عنوان ژورنال: Cytokine & Growth Factor Reviews
سال: 2005
ISSN: 1359-6101
DOI: 10.1016/j.cytogfr.2005.04.007